For more information please contact Prof. dr. Xevi Casadevall i Solvas, tel.: +32 16 37 71 03, mail: email@example.com.You can apply for this job no later than December 15, 2021 via the online application tool
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The Division of Mechatronics, Biostatistics and Sensors (MeBioS) performs groundbreaking research on innovative sensor technologies and the associated data analysis methods to understand and control the quality of products and ongoing processes.
Recent years have seen a surge in the development of microfluidic platforms for a wide diversity of applications, from diagnostics to new fundamental science studies. Microdroplet-based platforms (a particular branch of microfluidics capable of generating and manipulating identical, fL to nL-sized droplets at kHz rates) has spearheaded several revolutionary High-Throughput Screening (HTS) assays, notably for applications in single cell omics. Yet, other promising HTS applications of droplet-based microfluidics (such as drug screening) remain largely untapped due to the impossibility of current droplet generation strategies to handle drug libraries in a combinatorial manner.
The first phase of this project aims to develop a strategy to solve the aforementioned limitation of droplet-based technology by developing a hybrid microfluidic-liquid handling platform with the capacity of generating large droplet libraries with distinct chemical payloads. Your tasks will involve:
In the second phase of this project you will adapt this platform to enable the production of/experimentation with patient-derived organoids, with the aim of screening and selecting optimal combinatorial treatments for Cystic Fibrosis (CF) patients not eligible for registered modulator treatments (which currently comprise 10% of the ofthe total population of CF patients)
Are you an energetic person, able to both think critically and creatively in scientific terms while also being effective at overcoming technical challenges? Are you keen on working at the crossroads of several disciplines (from engineering to biomedicine)? Then you may be the perfect scientist to join our team.
The ideal candidate will already possess several od the following skills:
Important: preference will be given to PhD candidates who hold an MS degree from an European institution or that can obtain a "recognition of foreign qualification" from NARIC (https://www.naricvlaanderen.be/en/naric-vlaanderen)