For more information please contact Mrs. Ingrid Arijs, tel.: +32 16 37 74 61, mail: firstname.lastname@example.org.
You can apply for this job no later than December 01, 2020 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
The Laboratory of Translational Genetics (headed by Diether Lambrechts) at the VIB Center for Cancer Biology in KU Leuven is located in the University Hospital Campus, Leuven, Belgium. The lab has longstanding collaborations with oncologists at the University Hospital Leuven and conducts translational research in numerous clinical trials run by the oncologists.
Currently, the lab is capitalizing on these connections with an ambitious new initiative that aims to merge the exciting new field of single-cell analysis with clinical studies collecting tumor biopsies serially sampled from patients treated with immune checkpoint inhibitors and/or angiogenesis inhibitors. Via a single-cell accelerator initiative, the lab has early access to the newest single-cell multi-omics technologies (scRNA-seq, scATAC-seq, scDNA-seq, CITE-seq, ECCITE-seq and spatial profiling). Currently, the major focus of the lab is to characterize how the tumor micro-environment determines tumor behavior and response to cancer therapies.
1. Thienpont et al. Tumor hypoxia causes DNA hypermethylation by reducing TET activity. Nature 2016;537(7618): p. 63-68.
2. Lambrechts et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nature Medicine 2018;24(8):1277-128.
3. D’Anna et al. DNA methylation repels binding of HIF transcription 1 factors to maintain tumour immunotolerance. Genome Biology, 2020.
4. Qian et al. A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling. Cell Research, 2020.
In your role as postdoc, you will have the opportunity to shape and lead single-cell analysis projects to elaborate why immune cells behave differently in the tumor micro-environment in terms of cancer immunotherapy response. You will be in charge and spearheading this exciting and state-of-the-art research project, but you must also have good communication skills, have a collaborative spirit and be willing to work as part of a research team. You provide advice and guidance to PhD students where applicable. You need to be able to organize and troubleshoot your work independently, document it thoroughly and communicate results and experience with the team in a transparent and professional manner.
We are looking for a postdoc who is highly motivated, well organized and dynamic with a high level of independence and creative thinking: