For more information please contact Prof. dr. Alejandro Sifrim, mail: email@example.com or Prof. dr. Stein Aerts, mail: firstname.lastname@example.org.You can apply for this job no later than November 30, 2020 via the online application tool
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A PhD position is available for a computational biologist at the Center of Human Genetics, KU Leuven. The position will be co-supervised by Prof. Alejandro Sifrim (Laboratory of Multi-omic Integrative Bioinformatics) and Prof. Stein Aerts (Laboratory of Computational Biology).
In this position you will be responsible for the development and implementation of data analysis strategies and pipelines for cutting-edge in situ expression assays, including 10X Genomics Visium and Cartana technologies. This will require novel method development, leveraging state-of-the-art machine (deep) learning technologies to process large-scale imaging and sequencing datasets in a high-performance computing environment. As part of the newly established Leuven Single-Cell Institute and Spatial Omics Core, the developed analysis pipelines will cater to a broad user base and biological application domains including studies into Crohn’s disease, Parkinson’s disease, and cancer in the host labs.
This project is a close collaboration between the Laboratory of Multi-omic Integrative Bioinformatics (LMIB) and the Laboratory of Computational Biology (LCB), at the Department of Human Genetics of the KU Leuven and the Center for Brain and Disease Research at VIB. The LMIB lead by Prof. Alejandro Sifrim is a newly established team focusing on computational spatial multi-omic method development, from data pre-processing to downstream integrative analyses. We are also part of global initiatives such as the Gut Cell Atlas (part of the Human Cell Atlas) effort. The LCB focuses on computational methods for single-cell regulatory genomics. Some of the recent LCB methods includes SCENIC, cisTopic, and ScoMap.
You will play a key role in the establishment of innovative analytical pipelines for spatial expression profiling technologies and applying these pipelines to various biological question domains.
Most challenging aspects of the role:
Essential knowledge, skills, and experience required:
Additional desirable skills and experience:
We offer funding for a full-time PhD position (1 year contracts, renewable to 4 years after positive evaluation), but we also invite candidates to apply for (inter)national external funding.
You will work in an intellectually challenging and stimulating environment with state-of-the art facilities. KU Leuven is a research intensive, internationally oriented university that carries out both fundamental and applied scientific research. It is highly inter- and multidisciplinary focused and strives for international excellence. In this regard, it actively works together with research partners in Belgium and abroad. It provides its students with an academic education that is based on high-quality scientific research. You will work in Leuven, a historic, dynamic and lively city located in the heart of Belgium, within 20 minutes from Brussels, the capital of the European Union, and less than two hours from Paris, London and Amsterdam. The salary will be in accordance with the University salary scales for doctoral researchers.