Please send your CV, motivation letter, publication list (including citation numbers and impact factors) and contact information for three references to email@example.com
Starting date: To be negotiated. Any date after January 1st 2020.
You can apply for this job no later than December 31, 2019 via the online application toolKU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
The laboratory for Disease Mechanisms in Cancer (KU Leuven, Belgium) is looking for a motivated postdoctoral researcher. Our team studies the biology of acute lymphoblastic leukemia (ALL), and in particular we focus on the role of mutations in ribosomal proteins and their association with other mutations in ALL.
Accumulation of mutations in ALL does not occur randomly, and particular lesions show significant co-occurrence or mutually exclusivity in the leukemia cells. This project aims at studying the molecular biological mechanisms by which co-occurring oncogenic events in T-cell ALL cooperate with each other to drive leukemia development, and how this can result in new vulnerabilities of the leukemia cells to drug treatment.Website unit
Our team identified mutations in ribosomal proteins in cancer (www.LDMC.be). The candidate will be responsible for executing the work related to the establishment of mouse models for ribosome defective ALL and using these models to explore co-operation between ribosome defects and co-occurring oncogenic events.
This work is part of a larger collaborative project involving Prof. Kim De Keersmaecker (KU Leuven), Prof.Jan Cools (KU Leuven – VIB), Prof. Johan Maertens (UZ Leuven – KU Leuven), Prof. Heidi Segers (UZ Leuven – KU Leuven) and Prof. Nancy Boeckx (UZ Leuven –KU Leuven), in which additional oncogenes in ALL are studied. The successful applicant will be responsible for coordination of this larger project and for supervising students working on different aspects of the project.