POSTDOCTORAL POSITION: DECODING CELLULAR HETEROGENEITY

23 January 2019

Get in touch!

Interested?

For more information please contact Prof. dr. Bernard Thienpont, tel.: +32 16 37 32 08, mail: bernard.thienpont@kuleuven.be.

You can apply for this job no later than February 24, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Apply before 24 February 2019

The Laboratory for Functional Epigenetics is looking for a Post-doc to join our team to investigate the role of the epigenome in controlling transcriptional heterogeneity.

We are a young and dynamic lab that is part of KU Leuven, Belgium’s highest-ranked university. The KU Leuven is a leading European research university, which for 3 consecutive years already ranks first in Europe in terms of innovation (Reuters). During your stay, you will be embedded in a team of local experts on single cell analyses, as we are part of the SymBioSys network aiming to advance computational methods in single cell analyses, and of the Leuven Cell Center, which joins research capabilities of several labs with a major focus on applications of single cell omics technologies. As a research unit flanking Belgium’s biggest hospital, we have several ongoing collaborations with clinicians for patient sample procurement, to maximize potential clinical impact.

Website unit

Responsibilities

The Laboratory for Functional Epigenetics is looking for a Post-doc to join our team to investigate the role of the epigenome in controlling transcriptional heterogeneity. Cellular heterogeneity is a key aspect of physiology and affects the occurrence and progression of diseases such as cancer. The biological mechanisms underlying cellular variability and heterogeneity have remained vastly underexplored. This is at least partly because heterogeneity is often obscured in bulk cell omics analyses. The advent of single cell omics technologies, however, has opened up exciting new opportunities to study heterogeneity at the cellular level, the fundamental unit of biology. 

In our quest to understand the role of the epigenome in controlling cellular heterogeneity, we are looking for a researcher eager to establish novel computational methods. You will develop bio-informatic pipelines and tools aimed at quantifying heterogeneity in single cell omics datasets. The latter includes transcriptomic, epigenomic and open chromatin analyses of tumours, as well as multi-omic combinations thereof. You will also help in project and manuscript drafting, and apply for independent funding. We can offer cross-training in both computational and experimental work, according to your needs and interests. 

Profile
  • Applicants should hold a PhD in bioinformatics, engineering, biology or biomedicine with additional training in bioinformatics. 
  • A publication record in bioinformatics, (epi)genetics or biomedicine.
  • We are explicitly looking for innovative, creative personalities with ambition and a hands-on, can-do attitude.
  • Ample experience in programming and data analysis is required.
  • Organizational and time management skills, and an ability to work independently.
  • Knowledge of statistics, epigenetics and/or NGS data is an important asset.
  • Motivated PhDs of all nationalities with a strong commitment to basic and/or clinical research are encouraged to apply. 
Offer
  • Excellent conditions for bio-informaticians within a team specialized in epigenetics, genetics and oncology, generating high-impact discoveries (cf. recent publications in Nature, Cell, Nature Medicine).
  • Access to state-of-the-art computing infrastructure and single cell omics equipment.
  • A stimulating and diverse research program in a world-class academic environment.
  • A position up to 3 years at a competitive salary.
  • The opportunity to supervise master and PhD students.
  • Start date: as soon as possible - the position is open effective immediately.