PHD PROJECT: ELUCIDATING THE INTERPLAY OF TORC1-SCH9 NUTRIENT SIGNALING, PH MANAGEMENT AND INTER-ORGANELLE COMMUNICATION

ref. BAP-2021-577

19 July 2021

Apply before 30 August 2021

The Functional Biology group of KU Leuven is a dynamic team conducting high-level research on mechanisms underlying nutrient signaling, pH and calcium homeostasis and the functioning of different organelles. The team uses this knowhow to develop yeast models allowing to get fundamental insight in the pathobiology of a variety of human proteopathies.

Project

Cells of all living organisms are equipped with complex and interconnected signal transduction pathways enabling them to make appropriate changes in cell growth and metabolism in response to environmental changes. The Functional Biology group has a long-standing tradition in studying the signaling network that allows yeast cells to properly respond to nutritional signals in order to extend cellular lifespan. This project focusses on the protein kinase Sch9 and its central role in nutrient signaling. It is well established that Sch9 receives input from two signaling complexes, the first called TORC1, that senses nutrient availability, and the second called SNF1, that senses the cellular energy levels. However, more recently we found that Sch9 also receives information on the functioning of vacuoles and mitochondria, and that it may control a system allowing for organelle pH management. By acting as integrator of these different signals, it appears that Sch9 can function as molecular switch that opens or closes specific signaling circuits enabling to enhance either nutrient uptake, storage, or recycling, which are all processes that have a major impact on cellular ageing and longevity. We want to understand how this Sch9-dependent molecular switch operates.

Profile

A Master degree in Biology, Biochemistry, Biomedical Sciences, Bio-engineering or equivalent is a must. You have good knowledge of molecular biology, cell biology and genetics.

Applicants must also have a competitive profile and be eligible to apply for an FWO fellowship in fundamental research or strategic basic research (see https://www.fwo.be/en/fellowsh... addition, you:

● are an autonomous, sociable colleague.

● are eager to learn, and have a lively interest in scientific research.

● have excellent research skills and a strong interest in molecular and cell biological methods.

● conduct research following the lab rules as well as rules of scientific integrity.

● are proficient in English and have good communication skills, both orally and in writing.

● are willing to supervise Bachelor and Master students.

● have (an interest in learning) basic bioinformatics and statistical analysis skills.

● have experience with international mobility is a plus, though not obligatory.

● are efficient and stress resistant, and able to respect deadlines.

Offer

We offer a full-time predoctoral position at the Laboratory of Functional Biology, Belgium. You will work in a stimulating research environment and contribute to the team spirit of our young research group consisting of several PhD students, technicians and postdocs.

The initial contract can be extended to fund a 4-year PhD project provided a positive evaluation or by obtaining a competitive FWO fellowship.

The salary will be in accordance with the University salary scales for doctoral researchers.

KU Leuven is one of Europe's top universities and is located in the vibrant city of Leuven, which has a strong international appeal. For more information on the University of Leuven visit: www.kuleuven.be/english/.

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More information please contact Prof. dr. Joris Winderickx, tel.: +32 16 32 15 16, mail: joris.winderickx@kuleuven.be.You can apply for this job no later than August 30, 2021 via https://www.kuleuven.be/person...

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