For more information please contact Prof. dr. Diether Lambrechts, mail: email@example.com or Mrs. Ingrid Arijs, tel.: +32 16 37 74 61, mail: firstname.lastname@example.org.
You can apply for this job no later than February 15, 2020 via the online application tool
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The Laboratory of Translational Genetics (headed by Diether Lambrechts) at the VIB Center for Cancer Biology and the Department of Human Genetics in KU Leuven is located in the University Hospital Campus, Leuven, Belgium.
The lab has longstanding collaborations with oncologists at the University Hospital Leuven and conducts translational research in numerous clinical trials run by the oncologists. Currently, the lab is capitalizing on these connections with an ambitious new initiative that aims to merge the exciting new field of single-cell analysis with clinical studies collecting tumor biopsies serially sampled from patients treated with immune checkpoint inhibitors and/or angiogenesis inhibitors. Via a single-cell accelerator initiative, the lab has early access to the newest single-cell multi-omics technologies (scRNA-seq, ATAC-seq, DNA-seq, CITE-seq, CROP-seq and spatial profiling). Currently, the major focus of the lab is to characterize how the tumor micro-environment determines tumor behavior and response to cancer therapies. This exciting and actual research line bears a lot of translational potential, as managing the levels of hypoxia in solid tumors by anti-angiogenic strategies represents a major yet incompletely understood challenge, while the field of immunotherapy is rapidly expanding - yet desperately in need of biomarkers predicting clinical response.
1. Thienpont et al. Tumor hypoxia causes DNA hypermethylation by reducing TET activity. Nature 2016;537(7618): p. 63-68.
2. Vanderstichele et al. Chromosomal instability in cell-free DNA as a highly specific biomarker for detection of ovarian cancer in women with adnexal masses. Clinical Cancer Research, 2017. 23(9): p. 2223-2231.
3. Lambrechts et al. Phenotype molding of stromal cells in the lung tumor microenvironment. Nature Medicine 2018;24(8):1277-128.
4. Smeets et al. Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy. Nat Commun, 2018. 9: p. 4112.
5. Heylen et al. Age-related changes in DNA methylation affect renal histology and post-transplant fibrosis. Kidney Int. 2019 Nov;96(5):1195-1204.
In your role as a postdoc, you will have the opportunity to shape and lead single-cell analysis projects to elaborate why immune cells behave differently in the tumor micro-environment in terms of cancer immunotherapy response. You will be in charge and spearheading this exciting and state-of-the-art research project, but you must also have good communication skills, have a collaborative spirit and be willing to work as part of a research team. You provide advice and guidance to PhD students where applicable. You need to be able to organize and troubleshoot your work independently, document it thoroughly and communicate results and experience with the team in a transparent and professional manner.
We are looking for a postdoc who is highly motivated, well organized and dynamic with a high level of independence and creative thinking: