For more information please contact Prof. dr. Lieve Moons, tel.: +32 16 32 39 91, mail: firstname.lastname@example.org or Mrs. Lies De Groef, tel.: +32 16 37 37 64, mail: email@example.com.
Applicants should submit a detailed Curriculum Vitae, a concise letter of motivationand two reference letters to their online application.
You can apply for this job no later than June 30, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
The quest for neuroprotective and/or regenerative therapies to tackle these degenerative disorders and central nervous system (CNS) trauma is a central theme in our research.
The NCDR has a strong interest in defining cellular/molecular mechanisms underlying neurodegeneration, neuroinflammation and regeneration in the eye/visual system of teleost fish and rodents (for more info see: http://bio.kuleuven.be/df/LM/). We position the eye ‘as a window to the brain’, allowing preclinical research into pathological processes contributing to human neurodegenerative diseases. The quest for neuroprotective and/or regenerative therapies to tackle these degenerative disorders and central nervous system (CNS) trauma is a central theme in our research. As the CNS of adult mammals has a limited regenerative capacity, identifying cellular and molecular mechanisms that enable neuronal circuit regeneration and functional recovery indeed forms a critical step towards designing future pro-regenerative therapies. Besides a special interest in defining the role of neuroinflammatory processes in de- and regeneration, we study an essential component of the neuronal circuitry that has been overlooked for decades: the dendrites. Based on recent intriguing findings (Beckers et al. Mol Neurobiol. 2019;56(5):3175-3192), we hypothesize an antagonistic interplay between dendritic remodeling and axon outgrowth in the damaged CNS and are investigating intracellular energy channeling as an underlying mechanism. To tackle our research questions, we use mouse, zebrafish and killifish models and pursue a multidisciplinary approach in which advanced in vivo ocular imaging technologies, electrophysiology and visual function tests (optomotor, Y-maze visual acuity) are being combined with detailed morphological phenotyping using optical clearing, confocal & multiphoton microscopy, and post-mortem histological analyses to follow inflammatory, de- and regenerative processes. Besides, ex vivo/in vitro retinal tissue/cell cultures and state-of-the-art (single cell) multi-omics approaches are available to study the cellular/molecular pathways underlying neuroprotection/regeneration. All research runs within the recently established ‘Vision Core Leuven’, a preclinical animal platform which brings together cutting-edge technologies within the field of ocular imaging, electrophysiology and visual function testing in laboratory animals (see: http://www.visioncore.be/).
With the aforementioned research approaches we are generating big and complex data, including large omics datasets and spatiotemporal imaging data. To create and apply computational methods for the integrative analysis of complex biological processes in high-dimensional and multi-modal data sets and mine the data to the maximum, we are looking for a bioinformatics expert.
- Hands-on experience with omics analyses and expertise in bioinformatics or statistical modeling is required.
- Basic knowledge of molecular biology is an asset.
- Hands-on experience with 2-photon imaging and advanced image analysis is an asset.
Financing is available, preferably also with later application for a Marie Skłodowska-Curie Actions Individual Fellowship, Belgian FWO post-doctoral fellowship or equivalent.
KU Leuven, located in a vibrant student town in Flanders, Belgium, seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be