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KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.
we are looking for a motivated post-doc willing to supervise the fish-related research.
The NCDR has a strong interest in defining cellular/molecular mechanisms underlying neurodegeneration, neuroinflammation and regeneration in the eye/visual system of teleost fish and rodents (for more info see: http://bio.kuleuven.be/df/LM/). The quest for neuroprotective and/or regenerative therapies to tackle neurodegenerative disorders and central nervous system (CNS) trauma continues to be a central theme in our research. Despite intensive research efforts, induction of regeneration and subsequent functional recovery of the injured mammalian CNS remains a challenge, which makes the search for new pro-regenerative molecules essential, especially in an aging environment. In contrast to mammals, teleost fish have a remarkable neurogenic and regenerative potential in their adult CNS, already making them a preferred model organism in a myriad of comparative studies investigating the underlying mechanisms of successful regeneration. Moreover, over the past decade, several teleost species, such as the zebrafish (Danio rerio) and the African turquoise killifish (Nothobranchius furzeri), have been exploited in gerontology research. They are ideally suited to study the contribution of intrinsic and extrinsic molecular players to successful regeneration, also in an aging context. Besides a special interest in defining the role of neuroinflammatory processes in axon regeneration, we study an essential component of the neuronal circuitry overlooked for decades: the dendrites. Based on recent intriguing findings (Beckers et al. Mol Neurobiol. 2019;56(5):3175-3192), we hypothesize an antagonistic interplay between dendritic remodeling and axon outgrowth in the damaged fish CNS and are pursuing energy channeling as an underlying mechanism. To tackle our research questions, we use a multidisciplinary approach in which advanced in vivo ocular imaging technologies and visual function tests (optomotor, Y-maze visual acuity) are being combined with detailed morphological phenotyping using optical clearing, confocal & multiphoton microscopy, and post-mortem histological analyses to follow inflammatory, de- and regenerative processes. Besides, ex vivo/in vitro retinal tissue/cell cultures and state-of-the-art (single cell) multi-omics approaches are available to study the cellular/molecular pathways underlying neuroprotection/regeneration. All research runs within the recently established ‘Vision Core Leuven’, a preclinical animal platform which brings together cutting-edge technologies within the field of ocular imaging, electrophysiology and visual function testing in laboratory animals (see: http://www.visioncore.be/).
Within the aforementioned research lines, we are looking for a motivated post-doc willing to supervise the fish-related research.
- Basic knowledge of molecular biology, (immuno)histochemistry and microscopy is required
- Profound hands-on experience with in vivo experiments in (zebra/killi)fish is required
- Hands-on experience with in in vitro tissue/cell cultures or microfluidic approaches is an asset
- Hands-on experience with 2-photon imaging and image analysis software is an asset
- Hands-on experience with omics analyses and any expertise in bioinformatics or statistical modeling is an asset.
Financing is available, preferably also with later application for a Marie Skłodowska-Curie Actions Individual Fellowship, Belgian FWO post-doctoral fellowship or equivalent.
KU Leuven, located in a vibrant student town in Flanders, Belgium, seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be