PHD POSITION: IN VIVO MODEL FOR MECP2-RELATED DISEASES USING IPSC AND XENOTRANSPLANTATION

13 June 2019

Get in touch!

Interested?

For more information please contact Prof. dr. Hilde Van Esch, mail: hilde.vanesch@kuleuven.be.

Prof. dr. Hilde Van Esch - Department of Human genetics,  KU Leuven - Laboratory for the Genetic of Cognition - Herestraat 49 box 602, 3000 Leuven, Belgium


You can apply for this job no later than July 14, 2019 via the online application tool
KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Apply before 14 July 2019

Research in the Laboratory for Genetics of Cognition focuses on the clinical, genetic and molecular characterization of genetic disorders, associated with intellectual disability, X-linked as well as autosmal. Besides gene identification, applying the latest technology, we are also involved in developing models for neurodevelopmental disorders using the induced pluripotent stem cell technology. This research is done in close collaboration with several other groups at the Department of Human Genetics, as well as with groups in the KU Leuven and abroad.

Website unit

Project

Given the uniqueness of the human brain and the difficulty to study the brain of patients at the cellular and molecular levels (neuronal material/brain biopsy), the advent of human pluripotent stem cell (PSC) has offered new opportunities to study human neural development in health and disease. We apply since 2014 the iPSC technology, to model neurodevelopmental disorders in vitro, such as MECP2 duplication syndrome and CSC-KT syndrome. In this proposal, we will collaborate with Prof. Vanderhaeghen, whose laboratory pioneered in in vitro models of corticogenesis, whereby PSC are differentiated efficiently into cortical pyramidal projection neurons, and who has started to develop models of xenotransplantation, where human neurons derived from PSC can be transplanted into the mouse cortex, and then develop in vivo.

We will combine these two technologies in order to develop an in vivo human model of MECP2 related disorders, both Rett syndrome and MECP2 duplication syndrome

Profile
  • The candidate should have a strong academic record and holds a Master degree in Biomedical Sciences (Medicine, Biomedical Sciences) or BioEngineering (Cell- and Gene biotechnology)
  • Previous research experience, especially regarding tissue and cell culture is a plus, but not essential.
  • English is the main language and proficiency in written and spoken English is therefore crucial. 
  • You are a good writer, and you are not afraid of public speaking (e.g., delivering a conference presentation,...) 
  • The selected candidate is expected to write a doctoral thesis after 4 years.


Offer
  • We offer employment as a full-time doctoral researcher in a stimulating environment, but the student will be asked to apply for individual funding (f.e. FWO) at least once.
  • The possibility to participate in international conferences and collaborations.
  • Doctoral training at the Leuven International Doctoral School of Biomedical Sciences.