The laboratory of Clinical and Experimental Endocrinology at KU Leuven is currently hiring an enthusiastic and highly motivated PhD researcher to participate in our new research project “Better estimates of hormonal exposure to improve diagnosis and treatment in endocrine diseases”.
This project is funded by the TBM program of Research Foundation Flanders (Applied Biomedical Research with primary social finality – FWO Vlaanderen) and is in collaboration with Ghent University.
Despite the importance of free steroid hormone levels in determining physiological processes, clinical applicability of free steroid hormone levels is still hampered. This is due to the use of inaccurate and insensitive methods to measure total steroid hormone and binding protein concentrations, and - especially for free vitamin D - poorly validated calculators. However, measurement of free hormone concentrations is applicable to numerous clinical conditions and is also relevant for an aging and ever more obese general population.
The main goals of the BEED-ED project are to improve diagnostic accuracy of free steroid hormone measurements (with a focus on free testosterone and free vitamin D), to contribute to the knowledge on the clinical relevance thereof and to have a positive impact on the availability of free steroid hormone assessments in routine clinical diagnostic settings. As such, our project will lead to better targeted care of endocrine diseases in both the general population as well as in specific patient groups (such as obese patients, pregnant women, patients with chronic kidney disease, …).
This translates into three main research objectives:
(1) developing and validating accurate analytical methods for free steroid hormone measurements (by using equilibrium dialysis and mass spectrometry)
(2) evaluate and if needed improve/develop (disease-specific) free hormone calculators, with a specific focus on conditions where the binding protein milieu (production, metabolism, binding affinity) is altered, such as in patients with chronic kidney disease, obesity or during pregnancy
(3) define limitations and best clinical use of such calculators to develop an operational clinical sample workflow for direct measurements of free steroid hormone concentrations in selected samples.
For more information please contact Prof. dr. Leen Antonio, mail: email@example.com.You can apply for this job no later than July 30, 2021 via https://www.kuleuven.be/person...
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