PhD position

THE ROLE OF DENDRITIC REMODELING AND MITOCHONDRIA DYNAMICS IN AXONAL REGENERATION IN A MOUSE MODEL FOR GLAUCOMA

03 July 2018

Get in touch!

Interested?

For more information please contact prof. dr. Karl Farrow, mail: karl.farrow@nerf.be or prof. dr. Lieve Moons, mail: lieve.moons@kuleuven.be.

You can apply for this job no later than August 31, 2018 via the online application tool.


KU Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

Apply before 31 August 2018

PhD position starting Sept 1st in the laboratories of Karl Farrow (NERF) and Lieve Moons (Neural Circuit Development and Regeneration Research Group, Dept. Biology, KU Leuven). Candidates are expected to have a degree in life sciences, physical sciences or engineering, with a strong interest in neurodegenerative diseases and repair strategies. Prior experience in imaging, histology, molecular biology or computer science is an advantage.

This PhD project will be performed in two internationally recognized research groups that form a highly qualified and multidisciplinary team with broad expertise and a longstanding track record in the field. The PhD project will be performed in two laboratories from the Biology Departement at KU Leuven, under supervision of Profs. K. Farrow and L. Moons. Dr. L. Moons, is heading the Neural Circuit & Regeneration group and an expert in studying neurodegeneration and axonal regeneration in the injured visual system of both teleost fish and rodents. She brings expertise in in vivo zebrafish and mouse models of axonal injury. Her team also provides the competence to perform genetic manipulations and to use ex vivo retinal explant and in vitro retinal neuron cultures. The group recently established the Vision Core Leuven, a platform combining state-of-the-art technologies for ocular imaging, electrophysiology and visual function testing in laboratory animals. Dr. K. Farrow, who leads the Visual Neural Circuits lab, shows proficiency in neurophysiology of the retina and superior colliculus, and strengthens the team with his expertise in ex vivo/in vivo two-photon imaging and viral tracing techniques. Also his ability to perform automated high-throughput quantification of dendritic anatomy of retinal ganglion cells will be instrumental to this project. Thus, this project elegantly bridges the combined research interests of both teams and provides a superb training environment.

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Project

Description : PhD position starting Sept 1st in the laboratories of Karl Farrow (NERF) and Lieve Moons (Neural Circuit Development and Regeneration Research Group, Dept. Biology, KU Leuven). Candidates are expected to have a degree in life sciences, physical sciences or engineering, with a strong interest in neurodegenerative diseases and repair strategies. Prior experience in imaging, histology, molecular biology or computer science is an advantage. Interested applicants should send a statement of interest, CV and the contact information of 1-2 references to Karl Farrow.

Project : 

This project aims to determine if we can take advantage of the antagonistic interplay between dendritic and axon growth to develop a strategy to better promote axonal growth in an experimental model of neurodegeneration in the eye. This will involve characterizing the cell type dependency of this interplay; assessing the role of mitochondrial dynamics and the validation of potential molecules that enhances axonal growth in mice. The work will combine quantitative anatomy with ex-vivo and in-vivo imaging in mouse retinas using two-photon microscopy.

Profile

The candidate:

  • Is well organized and eager to learn new technologies.
  • Is creative and goal oriented.
  • Has good social skills and is a teamplayer.
  • Is flexible.
  • Has good communicative skills.
  • Is enthusiasticto obtain new expertise.
Offer

We offer :

  • An exciting working environment where quality, professionalism and human contacts are paramount.
  • The opportunity to be part of a dynamic team and provide a meaningful contribution to the identification of molecular targets to enhance regenerative growth and reconnection, applicable to neurodegenerative diseases and promoting neural repair.