POSTDOCTORAL REASEARCHER IN ATRIAL MYOPATHY BY SINGLE CELL SEQUENCING.

03 May 2021

Get in touch!

Interested?

Please send your CV, motivation letter and 2 recommendation letters to Prof. Dr. H. Llewelyn Roderick, Email: (Llewelyn.roderick@kuleuven.be). Please also apply via the online portal of KU Leuven.

You can apply for this job no later than June 02, 2021 via the online application toolK

.U Leuven seeks to foster an environment where all talents can flourish, regardless of gender, age, cultural background, nationality or impairments. If you have any questions relating to accessibility or support, please contact us at diversiteit.HR@kuleuven.be.

(ref. BAP-2021-85)

Apply before 02 June 2021

The Laboratory of Experimental Cardiology at KULeuven is seeking a post-doctoral scientist to lead a new project to investigate the contribution of changes in the heterocellular composition of the atria and cell-cell interactions to the development of atrial fibrillation. Our lab is focussed on identifying mechanisms involved in cardiac remodelling during disease and ageing. We have particular interests in the role of the epigenome in controlling transcriptome changes underlying cardiomyocyte growth, maturation and proliferation and in signalling mechanisms that can bring about these changes (Thienpont et al., JCI 2017). We employ multiple approaches spanning from RNA- and ChIP-seq, single cell sequencing to super resolution imaging and physiological studies. These analyses are based on patient samples, small and large animal models including transgenics.

In this recently funded collaborative project with labs at the University of Ghent and Antwerp, snRNA/ATAC sequencing approaches combined with in situ analysis will be used to identify in human samples as well as in a pig model, mechanisms underlying tissue remodelling underlying the development of atrial fibrillation. Cell and animal models as well as mathematical modelling will be used to validate candidates and for exploring their potential as therapies. This is a collaborative project across multiple centres, which will provide the candidate with opportunities for developing their project, gaining new experiences, including in translational science and for broadening their networks. Candidates with experience and/or knowledge in the areas of cardiovascular biology, next generation sequencing approaches including single cell analysis, bioinformatics and bioimaging are particularly encouraged to apply although enthusiasm and dedication is most sought after.

The laboratory is highly international consisting of post-doctoral scientists, PhD students and technicians. The lab will support you in gaining expertise in necessary areas and through our excellent local and international collaborators and core facilities, you will have access to additional expertise and tools.

Our lab is embedded in the Department of Cardiovascular Sciences situated in the Biomedical Campus of KU Leuven, Belgium. It has the entire range of competences from basic science, over pre-clinical modeling to applied clinical and epidemiological research, taking a systems approach to the complexity of cardiovascular disorders. KU Leuven offers a stimulating environment for international students and support for junior scientists to achieve their ambitions and in career development.

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Responsibilities
  • Use cutting-edge approaches to seek novel mechanisms involved in AF development that may be targeted therapeutically.
  • Design and execute experimental work, analyse data and write manuscripts.
  • Participate and present at internal and international meetings.
  • Expected to publish data in top scientific journals.
Profile
  • Our ideal candidate holds a PhD degree in Biomedical Sciences, Cell Biology, Biochemistry or other similar domain of life sciences with working knowledge in relevant areas.
  • You have a demonstrated ability to perform high-level biomedical research with at least 1 first author paper in a reputed journal.
  • You are ideally experienced in NGS approaches, including RNA-Seq and/or bioinformatics. Experience in single cell methods is also an advantage.
  • Experience with NGS data processing and working knowledge of R and bioconductor packages would be an advantage.
  • Experience in cardiovascular research including animal models is desirable.
  • You enjoy collaborating with your colleagues and externally to scientific advance.
  • You have strong written and oral communication skills in English
  • You enjoy presenting your data to collaborators and to the community at scientific meetings.
  • You perform your research to the highest standards and integrity.
Offer

Our research team can offer you a position for 3 years with possibility for extension. within a stimulating and supportive environment in which you acquire expertise as a multidisciplinary researcher.
We also provide support to apply for independent funding from the national and international funding agencies including the Flemish Research Council (FWO) and the EU.