For more information please contact Prof. dr. Kim De Keersmaecker, mail: email@example.com
You can apply for this job no later than October 31, 2018 via the online application tool
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The laboratory for Disease Mechanisms in Cancer (Department of Oncology, KU Leuven) is looking for a motivated postdoctoral researcher. Our team has a long-standing interest in studying the biology of acute lymphoblastic leukemia (ALL), and in particular we focus on the role of mutations in ribosomal proteins and their association with other mutations in ALL. Accumulation of mutations in ALL does not occur randomly, and particular lesions show significant co-occurrence or mutually exclusivity in the leukemia cells. This project aims at studying the molecular biological mechanisms by which co-occurring oncogenic events in T-cell ALL cooperate with each other to drive leukemia development, and how this can result in new vulnerabilities of the leukemia cells to drug treatment.
The candidate will lead a new project to explore the co-operation between ribosome defects and co-occurring oncogenic events in T-cell ALL. The project will use cell-based and mouse models, proteomics, expression analysis and metabolomics.
This work is part of a larger collaborative project involving Prof. Kim De Keermaecker (KU Leuven), Prof. Jan Cools (KU Leuven – VIB), Prof. Johan Maertens (UZ Leuven – KU Leuven), Prof. Heidi Segers (UZ Leuven – KU Leuven) and Prof. Nancy Boeckx (UZ Leuven –KU Leuven), in which additional oncogenes in ALL are studied. The successful applicant is expected to provide support to the coordination of this larger project and for supervising students working on different aspects of the project.