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This PhD position will be well embedded in local expertise on single cell analyses, as we are part of the SymBioSys network aiming to advance computational methods in single cell analyses, and of the Leuven Cell Center, which joins research capabilities of several labs having a major focus on applications of single cell omics technologies.
The Laboratory for Functional Epigenetics is looking for a PhD candidate to join our team to investigate the role of the epigenome in generating transcriptional heterogeneity. Cellular heterogeneity is key to multiple aspects of normal development, physiology and to diseases such as cancer. However, the biological control of cellular variability and heterogeneity has remained vastly underexplored, in part because heterogeneity is often obscured in bulk cell omics analyses. The advent of single cell omics technologies however opens up exciting new opportunities to study heterogeneity at the cellular level, a fundamental unit of biology. To help us in our quest to understand the role of the epigenome in heterogeneity control, we are looking for a PhD candidate eager to develop novel computational methods to quantify heterogeneity in a single cell omics datasets. Single cell datasets will include transciptomic, epigenomic and open chromatin analyses of tumours, and multi-omic combinations thereof. Successful candidates will have the option of being cross-trained in both computational and experimental work.